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pentobarbital will lower the level or result of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Impact of coadministering a solid CYP3A4 inducer with fedratinib hasn't been examined.pentobarbital will lower the extent or impact of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism